Apnea means "no airflow." Obstructive sleep apnea was thought to be a disorder primarily of overweight, older men. But abnormal breathing during sleep can affect people of any age, any weight, and either sex. Researchers now know that in many cases of sleep apnea, the obstruction in the airways is only partial. Most people with sleep apnea have a smaller-than-normal inner throat and other subtle bone and soft-tissue differences.
On the other hand, it is during sleep that beta-amyloid residues are degraded to prevent plaque formation. It is the glymphatic system that is responsible for this and this phenomenon is called glymphatic clearance. Thus, during wakefulness, the AB burden is greater because the metabolic activity and oxidative stress are higher and there is no degradation of the protein by the glymphatic clearance whereas during sleep, the burden will be smaller as there will be less metabolic activity and oxidative stress in addition to the glymphatic clearance that occurs at this time.
Although we do not know the causual relationship, we know that the more the AD progresses, the more we find sleep disorders. In the same way, the more sleep disorders there are, the more the disease progresses, forming a vicious circle. Taken this into account, sleep disturbances are no longer a symptom of AD and relationship between sleep disturbances and AD is bidirectional.
With over 80 listed sleep disorders, and more that are being researched, it's important for patients suffering from the various types of sleep disorders to seek medical treatment. If you believe that your sleep problems may be caused by a disorder, there are many things you can do to solve your sleep issues from DIY tips and tricks such as practicing better sleep hygiene, to contacting a sleep clinic to schedule an inlab sleep study, or an at home sleep test for certain pre-screened disorders such as obstructive sleep apnea.
Keep a pen and paper next to your bed. If you're often kept awake by racing thoughts and worries and you tend to make to-do lists in your head, keep a pen or pencil and a small pad of paper handy and write them down. As you put each item down on paper, imagine yourself setting aside that concern. (Again, use a book light; don't turn on the overhead or a bright bedside light to write.)